Asiatic acid prevents lipid peroxidation and improves antioxidant cachet

Asiatic acid

Oxidative accent is a accepted pathogenesis of diabetes mellitus and Asiatic acid plays an important role in ameliorating those difficulties. The present abstraction was advised the careful furnishings of AA on adapted lipid peroxidation products, enzymic and nonenzymic antioxidants in streptozotocin (STZ)-induced diabetic rats.
Diabetes was induced in beginning rats by individual dosage STZ (40 mg/kg b.w.) injection. Diabetic rats showed decidedly added levels of claret glucose, thiobarbituric acerbic acknowledging substances, lipid hydroperoxides, aspartate aminotransferase, alanine aminotransferase, bilirubin, creatine kinase, urea, uric acid, creatinine and decreased levels of claret insulin. The activities of enzymatic antioxidants such as superoxide dismutase, catalase, glutathione peroxidase and glutathione-S-transferase and the levels of non-enzymatic antioxidants such as vitamin C, vitamin E and bargain glutathione were decreased in diabetic rats.
Oral analysis with Asiatic acid (20 mg/kg b.w.) showed abreast normalized levels of claret glucose, insulin, lipid peroxidation products, enzymatic and nonenzymatic markers in diabetic rats. The after-effects authenticate that Asiatic acid possesses almighty antioxidant aftereffect commensurable with glibenclamide in convalescent antihyperglycemia and attenuating antioxidant cachet in diabetic rats.