Natamycin is an antifungal biologic for contemporary ophthalmic administration. It is a tetraene polyene antibacterial acquired from Streptomyces natalensis. It possesses in vitro action adjoin a array of aggrandize and filamentous fungi, including Candida, Aspergillus, Cephalosporium, Fusarium and Penicillium. Although the action adjoin fungi is dose-related, natamycin is predominantly fungicidal. Natamycin is not able in vitro adjoin gram-positive or gram-negative bacteria. Contemporary administering appears to aftermath able concentrations of natamycin aural the corneal stroma but not in intraocular fluid.
LIke added polyene antibiotics, Natamycin inhibits fungal advance by bounden to sterols. Specifically, Natamycin binds to ergosterol in the claret membrane, preventing ergosterol-dependent admixture of vacuoles, as able-bodied as film admixture and fission. This differs from the apparatus of a lot of added polyene antibiotics, which tend to plan by altering fungal film permeability instead.